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The compound has been studied in trials lasting up to 68 weeks, which provides useful medium-term data but leaves questions about effects beyond 2 years of continuous use

doi: 10.3390/cells10081976 Pubmed Abstract CrossRef Google Scholar View reference in article 69 QuadrosEV

Aliment Pharmacol Ther 2002;16(11):1903-15

(b) ubiquitination and subsequent degradation of IB- by the 26S proteasome

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Activation of NF-B signaling pathway aggravates the inflammation of UC The NF-B signaling pathway is a central regulator of inflammation